WebMar 20, 2024 · Crystal structure of the complex of phospho pantetheine adenylyl transferase from Acinetobacter baumannii with two ascorbic acid (Vitamin-C) molecules. PDB DOI: 10.2210/pdb6JOG/pdb; Classification: TRANSFERASE; Organism(s): Acinetobacter baumannii; Expression System: Escherichia coli; Mutation(s): No ; Deposited: 2024-03-20 … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier …
25.7: Tetrahydrofolate- Folic Acid - Chemistry LibreTexts
WebInside the cell, 4'-phosphopantetheine was enzymatically converted back to CoA by the bifunctional enzyme CoA synthase. Phenotypes induced by intracellular CoA deprivation were reversed when exogenous CoA was provided. Our findings answer long-standing questions in fundamental cell biology and have major implications for the understanding … WebJan 25, 2024 · Vitamin B5 (pantothenic acid) has recently joined the club of immunostimulatory B vitamins. Vitamin B5 is a precursor of coenzyme A (CoA), an essential cofactor for energy metabolism and fatty acid oxidation. ... Extracellular 4’-phosphopantetheine is a source for intracellular coenzyme A synthesis. how much rest after weight lifting
Jump-starting CoA biosynthesis Nature Chemical Biology
WebJan 19, 2024 · Vitamin B5, or pantothenic acid, is one of the eight B vitamins that make up the B complex. Like all B vitamins, vitamin B5 is water-soluble and aids in converting carbohydrates into glucose to produce energy that fuels the body. Found in plants, animals, and humans, pantothenic acid is essential to most all forms of life. WebBinding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). Source: GOC:vw, GOC:mah Comment None History See term history for GO:0031177 at QuickGO … WebPhosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance Biochim Biophys Acta Proteins Proteom. 2024 Nov 30;1869 (2):140566. doi: … how do potholes affect the environment