Chitinase 3-like 1 promoter
WebOct 3, 2024 · Background: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of tumors, especially in glioma, and contributes to tumor progression. However, the definite role of CHI3L1 and involved pathway in glioma progression are not completely understood. Methods: CHI3L1 expression in human gliomas and its association with … Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass. YKL-40 is … See more Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This … See more YKL-40 has been linked to activation of the AKT pro-survival (anti-apoptotic) signaling pathway. YKL-40 promotes angiogenesis through VEGF-dependent and independent … See more As Alzheimer's disease progresses, soluble amyloid beta aggregates in the brain can induce the activation of microglia, which triggers synthesis of pro-inflammatory mediators. This leads to increased Chi3l1 expression in astrocytes. There is evidence that YKL-40 levels … See more It is assumed that YKL-40 plays a role in cancer cell proliferation, survival, invasiveness and in the regulation of cell-matrix interactions. It is suggested that YKL-40 is a marker … See more • Human CHI3L1 genome location and CHI3L1 gene details page in the UCSC Genome Browser. See more • Rathcke CN, Vestergaard H (June 2006). "YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis". Inflammation Research. 55 (6): 221–7. doi:10.1007/s00011-006-0076-y See more
Chitinase 3-like 1 promoter
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WebMar 4, 2024 · Background: Chitinase 3 like 1 protein (Chi3L1) is expressed in several cancers, and a few evidences suggest that the secreted Chi3L1 contributes to tumor development. However, the molecular mechanisms of intracellular Chi3L1 are unknown in the lung tumor development. WebMar 28, 2024 · Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability. Crystal structure of breast regression protein 39 (BRP39), a signaling glycoprotein expressed during mammary gland apoptosis, at 2.6 A resolution. CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor …
WebMar 21, 2024 · GeneCards Summary for CHI3L1 Gene. CHI3L1 (Chitinase 3 Like 1) is a Protein Coding gene. Diseases associated with CHI3L1 include Asthma-Related Traits 7 … WebGenetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40 In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway.
WebFeb 14, 2024 · Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. WebOct 19, 2015 · Here, we found that chitinase mRNA levels were 4.5-times greater when peanut seedlings were sprayed with 1.5 mM SA, as compared to water. The upstream …
WebMolecular characterization of the Ym1 promoter in transfected epithelial and macrophage cell lines revealed the presence of multiple signal transducers and activators of transcription 6 (STAT6) response elements that function in a combinatorial manner to mediate transcriptional responses to IL-4 [2].
WebMar 15, 2009 · Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases. Objectives: The genetic contribution of CHI3L1 gene to atopic susceptibility was investigated using an integrated population genetic and molecular analysis. swashbuckler fashionWebSep 9, 2014 · Correlation of chitinase 3-like 1 single nucleotide polymorphisms and haplotypes with uterine cervical cancer in Taiwanese women PLoS One. 2014 Sep 9 ... G/A), rs10399805 (-247, G/A) and rs4950928 (-131, C/G) in the promoter region, and one SNP rs880633 (+2950, T/C) in exon 5 were analyzed by real time polymerase chain … swashbuckler feats 2eWebJan 1, 2007 · The chitinase 3–like 1 gene (CHI3L1) is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular … skull at the tower halo infiniteWebSep 9, 2014 · Chitinase3-like1 (CHI3L1) is a glycoprotein encoded by the chitinase 3-like 1 ( CHI3L1) gene located on human chromosome 1q32.1 [1]. This glycoprotein is often referred to as YKL-40 or human cartilage glycoprotein-39 (HC gp-39) and is known to be a pro-inflammatory cytokine of chitinase [2], [3]. swashbuckler extraordinaireWebSep 14, 2024 · Chitinase-3-Like Protein 1* / genetics Gene Expression Regulation, Enzymologic* Gene Expression Regulation, Neoplastic* Humans Neoplasm Proteins* / biosynthesis Neoplasm Proteins* / genetics Organ Specificity Osteosarcoma* / enzymology Osteosarcoma* / genetics CHI3L1 protein, human Chitinase-3-Like Protein 1 Neoplasm … skull automatic watchWebBackground: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of tumors, especially in glioma, and contributes to tumor progression. However, the definite role of CHI3L1 and involved pathway in glioma progression are not completely understood. skull axe throwingWebChitinase 3-like-1 promotes intrahepatic activation of coagulation through induction of tissue factor in mice Authors Zhao Shan 1 , Xiaodong Liu 2 , Yuan Chen 1 , Meng Wang 1 , Yue Rachel Gao 1 , Liangguo Xu 1 , Wasim A Dar 3 , Chun Geun Lee 4 , Jack Angel Elias 4 5 , Pavel Davizon Castillo 6 , Jorge Di Paola 6 , Cynthia Ju 1 7 Affiliations skull astronaut tattoo forearm